Issue 1, 2022

Active single cell encapsulation using SAW overcoming the limitations of Poisson distribution

Abstract

We demonstrate the use of an acoustic device to actively encapsulate single red blood cells into individual droplets in a T-junction. We compare the active encapsulation with the passive encapsulation depending on the number of loaded cells as well as the created droplet volumes. This method overcomes the Poisson limitation statistical loading of cells for the passive encapsulation. In our experiments we reach a single cell encapsulation efficiency of 97.9 ± 2.1% at droplet formation rates exceeding 15 Hz.

Graphical abstract: Active single cell encapsulation using SAW overcoming the limitations of Poisson distribution

Supplementary files

Article information

Article type
Paper
Submitted
29 Sep 2021
Accepted
01 Dec 2021
First published
02 Dec 2021
This article is Open Access
Creative Commons BY license

Lab Chip, 2022,22, 193-200

Active single cell encapsulation using SAW overcoming the limitations of Poisson distribution

A. Link, J. S. McGrath, M. Zaimagaoglu and T. Franke, Lab Chip, 2022, 22, 193 DOI: 10.1039/D1LC00880C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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