Taming photocatalysis in flow: easy and speedy preparation of α-aminoamide derivatives

Abstract

α-Aminoamides are reiterative molecular subunits in transcendental molecules, which bear attractive functionalities for (bio)synthetic purposes. Herein, their preparation by harnessing flow photocatalysis is described, which provides significant improvements over other catalytic methods in terms of efficiency while outperforming an analogous batch setup. A reaction time of five minutes, operational simplicity and absence of purification steps for the isolation of final products evidence an enhanced performance.