Simple use of KOH allows the direct F to OH exchange of aromatic and heteroaromatic substrates under mechanochemical conditions. The reaction is performed in the absence of solvent with potassium hydroxide as OH source. As a result, this approach is both more atom economical and environmentally friendly than previously described methods for this transformation.
E. Rodrigo, R. Wiechert, M. W. Walter, W. Braje and H. Geneste, Green Chem., 2022, 24, 1469 DOI: 10.1039/D1GC04361G
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