Issue 12, 2022

Controlling desolvation through polymer-assisted grinding

Abstract

We demonstrate the ability to controllably desolvate a crystal-solvate system in a step-wise fashion through polymer-assisted grinding by varying the type and proportion of polymer agent used. A plausible mechanistic explanation is proposed based on a combination of experimental evidence and computational analysis. Specifically, Raman spectroscopy, total scattering pair distribution function analysis and computed reaction energies suggest that the desolvation process is associated with preferred interactions between the solvent molecules and specific polymers. This approach could potentially be extended to any type of material, including heat-sensitive materials, where classical desolvation by thermal processes is not possible, and provides an additional route for formulation processing.

Graphical abstract: Controlling desolvation through polymer-assisted grinding

Supplementary files

Article information

Article type
Paper
Submitted
02 Feb 2022
Accepted
18 Feb 2022
First published
22 Feb 2022
This article is Open Access
Creative Commons BY license

CrystEngComm, 2022,24, 2305-2313

Controlling desolvation through polymer-assisted grinding

M. W. Terban, L. Madhau, A. J. Cruz-Cabeza, P. O. Okeyo, M. Etter, A. Schulz, J. Rantanen, R. E. Dinnebier, S. J. L. Billinge, M. Moneghini and D. Hasa, CrystEngComm, 2022, 24, 2305 DOI: 10.1039/D2CE00162D

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