Neutral isocyanide-templated assembly of pillararene  and pseudorotaxanes†
Unprecedented pillararene–isocyanide pseudorotaxane complexes are reported. Extensive 1H-NMR experiments reveal remarkably strong binding affinities of alkyl diisocyanide guests (Ka > 105 M−1 in CDCl3) by pillararenes. Characterised by multinuclear 1H and 13C-NMR spectroscopy and single-crystal X-ray diffraction, it is demonstrated that pillararenes are capable of encapsulating a series of alkyl diisocyanides wherein either - or pseudorotaxanes can be formed by varying the alkyl chain length. Moreover, electron-deficient aryl isocyanides, are demonstrated to form inclusion complexes within the cavities of pillararenes stabilised by multiple C–H⋯π interactions.
- This article is part of the themed collection: 2022 Emerging Investigators