Issue 55, 2022

Oxamic acids: useful precursors of carbamoyl radicals

Abstract

This review article describes the recent development in the chemistry of carbamoyl radicals generated from oxamic acids. This mild and efficient method compares well with previous methods of generation of these nucleophilic radicals. The oxidative decarboxylation of oxamic acids can be mediated through thermal, photochemical, electrochemical or photoelectrochemical means, generating carbamoyl radicals, which may further add to unsaturated systems to provide a broad range of important amides. Oxidative decarboxylation of oxamic acids also offers a straightforward entry for the preparation of urethanes, ureas, and thioureas.

Graphical abstract: Oxamic acids: useful precursors of carbamoyl radicals

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Article information

Article type
Highlight
Submitted
05 Apr 2022
Accepted
16 Jun 2022
First published
16 Jun 2022

Chem. Commun., 2022,58, 7593-7607

Oxamic acids: useful precursors of carbamoyl radicals

I. M. Ogbu, G. Kurtay, F. Robert and Y. Landais, Chem. Commun., 2022, 58, 7593 DOI: 10.1039/D2CC01953A

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