Issue 40, 2022
From the journal:

Chemical Communications

Applicability of the nearest-neighbour model for pseudoknot RNAs†

Sagar Satpathi,a   Tamaki Endoh ORCID logo a  and  Naoki Sugimoto ORCID logo *ab  

* Corresponding authors

a Frontier Institute for Biomolecular Engineering Research (FIBER), Konan University, 7-1-20 Minatojima-minamimachi, Kobe, Japan

b Graduate School of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University, 7-1-20 Minatojima-minamimachi, Kobe, Japan
E-mail: sugimoto@konan-u.ac.jp
Fax: +81-78-303-1495
Tel: +81-78-303-1416

Abstract

The validity of the nearest-neighbour (NN) model was verified in an RNA pseudoknot (PK) structure. The thermodynamic parameters of the second hairpin stem (S2) region, which separates the PK from a hairpin structure, were monitored using CD and UV melting. Different PKs with identical NN base pairs in the S2 region exhibited similar thermodynamic parameters, highlighting the validity of the NN model in this RNA tertiary structure motif.

Graphical abstract: Applicability of the nearest-neighbour model for pseudoknot RNAs

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D1CC07094K
Article type
Communication
Submitted
17 Dec 2021
Accepted
18 Mar 2022
First published
22 Apr 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 5952-5955

Permissions

Request permissions

Applicability of the nearest-neighbour model for pseudoknot RNAs

S. Satpathi, T. Endoh and N. Sugimoto, Chem. Commun., 2022, 58, 5952 DOI: 10.1039/D1CC07094K

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements