Issue 59, 2022

Alkyne insertion into Cu–Al bonds and selective functionalization to form copper acyl compounds

Abstract

We report on the insertion of alkynes into heterometallic M–M′ bonds, producing (aluminylalkenyl)copper compounds which possess differential reactivity at the two derived M–C functions. Uniquely, this system is capable of controlling access to isolable syn or anti dimetallated alkenes, by employing either kinetic or thermodynamic control. Subsequent derivatization with CO is both stereoselective (to syn systems) and regioselective (to Cu–C bonds), leading to the formation of the first structurally characterized examples of copper acyl compounds - aided by the cooperative reactivity of the proximal aluminium centre.

Graphical abstract: Alkyne insertion into Cu–Al bonds and selective functionalization to form copper acyl compounds

Supplementary files

Article information

Article type
Communication
Submitted
06 May 2022
Accepted
22 Jun 2022
First published
24 Jun 2022
This article is Open Access
Creative Commons BY license

Chem. Commun., 2022,58, 8274-8277

Alkyne insertion into Cu–Al bonds and selective functionalization to form copper acyl compounds

C. McManus, A. E. Crumpton and S. Aldridge, Chem. Commun., 2022, 58, 8274 DOI: 10.1039/D2CC02578G

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