Issue 12, 2021
From the journal:

Organic Chemistry Frontiers

Regioselective, copper(i)-catalyzed, tandem sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides†

Ran Ding, ORCID logo *a   Ya-Li Liu,‡a   Hui Hao,‡a   Chuan-Yi Chen,‡a   Lei Liu, ORCID logo a   Nian-Shou Chen,a   Yu Guo ORCID logo a  and  Pei-Long Wang*bc  

* Corresponding authors

a College of Chemistry and Materials Engineering, Anhui Science and Technology University, Bengbu, Anhui, P. R. China
E-mail: dingran@mail.ustc.edu.cn

b School of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China
E-mail: wangpeilong1987@163.com

c Information College, Huaibei Normal University, Huaibei, Anhui, P. R. China

Abstract

A copper(I)-catalyzed sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides was developed. This transformation demonstrated a broad substrate scope and presented excellent regioselectivity after radical addition and subsequent deprotonation to form the derivatized 1,5-dihydro-2H-pyrrol-2-one scaffold in one pot.

Graphical abstract: Regioselective, copper(i)-catalyzed, tandem sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides

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Article information

DOI
https://doi.org/10.1039/D1QO00460C
Article type
Research Article
Submitted
26 Mar 2021
Accepted
06 May 2021
First published
07 May 2021

Org. Chem. Front., 2021,8, 3123-3127

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Regioselective, copper(I)-catalyzed, tandem sulfonylation-cyclization of 1,5-dienes with sulfonyl chlorides

R. Ding, Y. Liu, H. Hao, C. Chen, L. Liu, N. Chen, Y. Guo and P. Wang, Org. Chem. Front., 2021, 8, 3123 DOI: 10.1039/D1QO00460C

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