Tunable synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via a domino process

Abstract

A K₂CO₃-promoted tunable domino reaction between thioisatins and α-bromoketones was developed for the synthesis of benzothiophene fused pyranone and thiochromen fused furan derivatives via adjusting MgSO₄. The reaction proceeds via K₂CO₃-induced C–S bond cleavage followed by two-step condensation reactions. The significance of these novel domino reactions lies in the formation of the products that are not easily accessible via traditional synthetic methods.