Visible-light-induced C(sp3)–H functionalizations of piperidines to 3,3-dichloro-2-hydroxy-piperidines with N-chlorosuccinimide

Abstract

A visible-light-induced synthesis of 3,3-dichloro-2-hydroxy-piperidines via site-selective functionalizations of C(sp³)−H in N-substituted piperidines using easily available N-chlorosuccinimide as chlorine source was developed. Mechanistic investigations suggest that chlorine radical is involved in this transformation.