Issue 10, 2021

Unusual titanium-induced McMurry coupling of 4-oxo-4H-chromene-2-carbaldehydes enroute to bis-chromones

Abstract

Ti/Zn-mediated McMurry coupling of a series of 4-oxo-4H-chromene-2-carbaldehydes afforded unusual chemoselective CH2–CH2 tethered bis-chromones. Studying the reaction parameters and reagents further confirmed that the formation of unexpected coupled products is selective to 4-oxo-4H-chromene-2-carbaldehydes. This methodology demonstrated a simple and efficient route for the synthesis of bis-chromones.

Graphical abstract: Unusual titanium-induced McMurry coupling of 4-oxo-4H-chromene-2-carbaldehydes enroute to bis-chromones

Supplementary files

Article information

Article type
Paper
Submitted
24 Sep 2020
Accepted
01 Feb 2021
First published
11 Feb 2021

New J. Chem., 2021,45, 4705-4709

Unusual titanium-induced McMurry coupling of 4-oxo-4H-chromene-2-carbaldehydes enroute to bis-chromones

J. R. Yerrabelly, P. K. Bathini, H. Yerrabelly and K. Vadapalli, New J. Chem., 2021, 45, 4705 DOI: 10.1039/D0NJ04730A

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