Issue 3, 2021

Mechanistic models of microbial community metabolism


Microbial communities affect many facets of human health and well-being. Naturally occurring bacteria, whether in nature or the human body, rarely exist in isolation. A deeper understanding of the metabolic functions of these communities is now possible with emerging computational models. In this review, we summarize frameworks for constructing mechanistic models of microbial community metabolism and discuss available algorithms for model analysis. We highlight essential decision points that greatly influence algorithm selection, as well as model analysis. Polymicrobial metabolic models can be utilized to gain insights into host-pathogen interactions, bacterial engineering, and many more translational applications.

Graphical abstract: Mechanistic models of microbial community metabolism

Article information

Article type
Review Article
04 Nov 2020
25 Feb 2021
First published
23 Mar 2021
This article is Open Access
Creative Commons BY license

Mol. Omics, 2021,17, 365-375

Mechanistic models of microbial community metabolism

L. R. Dillard, D. D. Payne and J. A. Papin, Mol. Omics, 2021, 17, 365 DOI: 10.1039/D0MO00154F

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