Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

Nnamdi Akporji; Vani Singhania; Jade Dussart-Gautheret; Fabrice Gallou; Bruce H. Lipshutz

doi:10.1039/D1CC04774D

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Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water†

Nnamdi Akporji,

^a Vani Singhania,

^a Jade Dussart-Gautheret,

^a Fabrice Gallou

^b and Bruce H. Lipshutz

*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA
E-mail: lipshutz@chem.ucsb.edu
Web: http://www.chem.uscb.edu/lipshutzgroup
Fax: +1 805-893-8265
Tel: +1 805-893-2521

^b Novartis Pharma AG, CH-4057 Basel, Switzerland

Abstract

Bio-catalytic reactions involving ene-reductases (EREDs) in tandem with chemo-catalysis in water can be greatly enhanced by the presence of nanomicelles derived from the surfactant TPGS-750-M. Transformations are provided that illustrate the variety of sequences now possible in 1-pot as representative examples of this environmentally attractive approach to organic synthesis.

This article is part of the themed collections: Biocatalysis: A cross-journal collection and Green Synthesis

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Article information

DOI: https://doi.org/10.1039/D1CC04774D
Article type: Communication
Submitted: 31 Aug 2021
Accepted: 04 Oct 2021
First published: 04 Oct 2021

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Chem. Commun., 2021,57, 11847-11850

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Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

N. Akporji, V. Singhania, J. Dussart-Gautheret, F. Gallou and B. H. Lipshutz, Chem. Commun., 2021, 57, 11847 DOI: 10.1039/D1CC04774D

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Chemical Communications

Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water†

Abstract

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Nanomicelle-enhanced, asymmetric ERED-catalyzed reductions of activated olefins. Applications to 1-pot chemo- and bio-catalysis sequences in water

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