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Issue 46, 2021
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Late-stage ligand functionalization via the Staudinger reaction using phosphine-appended 2,2′-bipyridine

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Abstract

The ability of a phosphine-appended-2,2′-bipyridine ligand ((Ph2P)2bpy) to serve as a platform for late-stage ligand modifications was evaluated using tetrahedral (Ph2P)2bpyFeCl2. We employed a post-metalation Staudinger reaction to install a series of functionalized arenes, including those containing Brønsted and Lewis acidic groups. This reaction sequence represents a versatile strategy to both tune the ligand donor properties as well as directly incorporate appended functionality.

Graphical abstract: Late-stage ligand functionalization via the Staudinger reaction using phosphine-appended 2,2′-bipyridine

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Article information


Submitted
15 Mar 2021
Accepted
28 Apr 2021
First published
13 May 2021

Chem. Commun., 2021,57, 5718-5721
Article type
Communication

Late-stage ligand functionalization via the Staudinger reaction using phosphine-appended 2,2′-bipyridine

D. Taher, J. R. Wilson, G. Ritch, M. Zeller and N. K. Szymczak, Chem. Commun., 2021, 57, 5718
DOI: 10.1039/D1CC01407B

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