Issue 20, 2021
From the journal:

Chemical Communications

A novel minimal motif for left-handed G-quadruplex formation†

Poulomi Das,a   Fernaldo Richtia Winnerdy,ab   Arijit Maity,a   Yves Mechulamc  and  Anh Tuân Phan ORCID logo *ab  

* Corresponding authors

a School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: phantuan@ntu.edu.sg

b NTU Institute of Structural Biology, Nanyang Technological University, Singapore 636921, Singapore

c Laboratoire de Biologie Structurale de la Cellule (BIOC), Ecole Polytechnique, CNRS-UMR7654, Institut Polytechnique de Paris, Palaiseau 91128, France

Abstract

A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

Graphical abstract: A novel minimal motif for left-handed G-quadruplex formation

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Article information

DOI
https://doi.org/10.1039/D0CC08146A
Article type
Communication
Submitted
20 Dec 2020
Accepted
29 Jan 2021
First published
30 Jan 2021

Chem. Commun., 2021,57, 2527-2530

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A novel minimal motif for left-handed G-quadruplex formation

P. Das, F. R. Winnerdy, A. Maity, Y. Mechulam and A. T. Phan, Chem. Commun., 2021, 57, 2527 DOI: 10.1039/D0CC08146A

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