SCHEDULED MAINTENANCE
We generated a novel G-quadruplex (G4)-specific endonuclease by fusing a G4 recognition domain of the RHAU helicase with a cleavage domain of the Fok1 nuclease. The fusion protein can specifically bind a parallel G4 and cleave a double-stranded DNA (dsDNA) next to it. The new endonuclease could be used to detect a G4 in a long dsDNA, providing a useful tool for mapping the formation of G4s in the genome.
D. T. Dang, L. T. A. Nguyen, T. T. T. Truong, H. D. Nguyen and A. T. Phan, Chem. Commun., 2021, 57, 4568 DOI: 10.1039/D0CC05890D
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