Size-dependent optical extinction of MoS2 nanosheets and their aptamer-induced dispersion behavior for the label-free detection of Escherichia coli O157:H7†
For aptamer-modified nanomaterial biosensors label-free detection methods are desirable due to them being simple and low in cost. Among these methods, nanomaterial aggregation for signal conversion is common, using materials such as gold nanoparticles. However, for MoS2 nanosheets (MoS2-NSs), signal conversion of its aggregation is difficult, resulting in the limited development of its label-free sensing applications. Herein, for the first time, the extinction spectrum has been employed to quickly transform the signal of MoS2-NS aggregation and reveal the size-dependent extinction response of MoS2-NS aggregation. Moreover, the size-dependent optical extinction behavior of MoS2-NSs, using aptamers to induce the dispersion of the MoS2-NSs and greatly improve their ability to identify targets, is studied. Importantly, this method has been employed to achieve the label-free detection of Escherichia coli O157:H7. The present investigation shows the promising use of MoS2-NSs for the development of label-free detection.