Issue 17, 2021

Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium(v) complex

Abstract

The catalytic enantioselective oxidative hetero-coupling of arenols using a chiral vanadium(V) complex has been developed. The coupling of hydroxycarbazole derivatives with various arenols provided axially chiral biarenols with high chemo-, regio-, and enantioselectivities. The reaction took place under mild conditions and exhibited satisfactory functional group tolerance. Aerobic oxidative hetero-coupling with β-ketoesters also proceeded with high chemo- and stereoselectivities under slightly modified reaction conditions.

Graphical abstract: Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium(v) complex

Supplementary files

Article information

Article type
Research Article
Submitted
22 May 2021
Accepted
22 Jun 2021
First published
23 Jun 2021

Org. Chem. Front., 2021,8, 4878-4885

Chemo- and enantioselective hetero-coupling of hydroxycarbazoles catalyzed by a chiral vanadium(V) complex

M. Sako, K. Higashida, G. T. Kamble, K. Kaut, A. Kumar, Y. Hirose, D. Zhou, T. Suzuki, M. Rueping, T. Maegawa, S. Takizawa and H. Sasai, Org. Chem. Front., 2021, 8, 4878 DOI: 10.1039/D1QO00783A

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