Issue 31, 2021

Silicon compounds as stoichiometric coupling reagents for direct amidation

Abstract

Despite being one of the most frequently carried out chemical reactions in industry, there is currently no amidation protocol that is regarded as safe, high yielding, environmentally friendly and inexpensive. The direct amidation of a carboxylic acid with an amine is viewed as an inherently good solution for developing such a protocol. Since the 1960s, there has been a gradual development in the use of silicon reagents for direct amidation. This review covers the methods published to April 2021 for silicon reagent mediated direct amidation of a carboxylic acid with an amine. This review also covers the use of polymeric SiO2 to promote direct amidation.

Graphical abstract: Silicon compounds as stoichiometric coupling reagents for direct amidation

Article information

Article type
Review Article
Submitted
24 May 2021
Accepted
18 Jul 2021
First published
22 Jul 2021
This article is Open Access
Creative Commons BY license

Org. Biomol. Chem., 2021,19, 6746-6760

Silicon compounds as stoichiometric coupling reagents for direct amidation

J. J. Davies, D. Christopher Braddock and P. D. Lickiss, Org. Biomol. Chem., 2021, 19, 6746 DOI: 10.1039/D1OB01003D

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