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Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

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Abstract

Cascade reactions are green and powerful transformations for building multiple carbon–carbon bonds in one step. Through a relay olefination and radical addition process, we were able to develop the cascade Wittig/hydroalkylation reactions induced by visible light. This metal-free radical approach features mild conditions, robustness, and excellent functionality compatibility. It allows access to saturated C3 homologation products directly from aldehydes or ketones. The synthetic utility of this method is demonstrated by a two-step synthesis of indolizidine 209D.

Graphical abstract: Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

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Article information


Submitted
08 Jan 2021
Accepted
08 Feb 2021
First published
08 Feb 2021

Green Chem., 2021, Advance Article
Article type
Communication

Visible-light induced metal-free cascade Wittig/hydroalkylation reactions

P. Miao, R. Li, X. Lin, L. Rao and Z. Sun, Green Chem., 2021, Advance Article , DOI: 10.1039/D1GC00091H

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