Jump to main content
Jump to site search

Issue 45, 2021
Previous Article Next Article

Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

Author affiliations

Abstract

A library of N-thiocarboxyanhydrides (NTAs) derived from natural amino acids with benign byproducts and controlled H2S-release kinetics is reported. Minimal acute in vitro toxicity was observed in multiple cell lines, while longer-term toxicity in cancer cells was observed, with slow-releasing donors exhibiting the greatest cytotoxic effects.

Graphical abstract: Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

Back to tab navigation

Supplementary files

Article information


Submitted
10 Mar 2021
Accepted
22 Apr 2021
First published
06 May 2021

Chem. Commun., 2021,57, 5522-5525
Article type
Communication

Amino acid-based H2S donors: N-thiocarboxyanhydrides that release H2S with innocuous byproducts

K. Kaur, P. Enders, Y. Zhu, A. F. Bratton, C. R. Powell, K. Kashfi and J. B. Matson, Chem. Commun., 2021, 57, 5522
DOI: 10.1039/D1CC01309B

Social activity

Search articles by author

Spotlight

Advertisements