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Issue 45, 2021

Fluorescent probe for early mitochondrial voltage dynamics

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Abstract

Mitochondrial voltage dynamics plays a crucial role in cell healthy and disease. Here, a new fluorescent probe to monitor mitochondrial early voltage variations is described. The slowly permeant probe is retained in mitochondria during measurements to avoid interferences from natural membrane potential by incorporating an hydrolizable ester function. Voltage, local polarity, pH parameters and transmembrane dynamics were found to be deeply correlated opening a approach in mitochondrial sensing.

Graphical abstract: Fluorescent probe for early mitochondrial voltage dynamics

Supplementary files

Article information


Submitted
12 Apr 2021
Accepted
04 May 2021
First published
04 May 2021

Chem. Commun., 2021,57, 5526-5529
Article type
Communication

Fluorescent probe for early mitochondrial voltage dynamics

C. Hernández-Juárez, R. Flores-Cruz and A. Jiménez-Sánchez, Chem. Commun., 2021, 57, 5526 DOI: 10.1039/D1CC01944A

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