Jump to main content
Jump to site search

Issue 22, 2021
Previous Article Next Article

Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release

Author affiliations

Abstract

A hyaluronidase-responsive polysaccharide supramolecular assembly was constructed from an amphiphilic β-cyclodextrin bearing seven hexylimidazolium units (AMCD), adamantyl-grafted hyaluronic acid, and chlorambucil, which showed specific cancer cell targeting and controlled drug release abilities. Interestingly, ternary supramolecular assembly can disassemble in the presence of hyaluronidase, and the released AMCD can assemble with ATP to form a stable 1 : 1 complex, which enhanced the efficacy of chlorambucil on cancer chemotherapy by inhibiting ATP hydrolysis.

Graphical abstract: Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release

Back to tab navigation

Supplementary files

Article information


Submitted
17 Jan 2021
Accepted
06 Feb 2021
First published
06 Feb 2021

Chem. Commun., 2021,57, 2812-2815
Article type
Communication

Multicharge β-cyclodextrin supramolecular assembly for ATP capture and drug release

C. Chen, Y. Chen, X. Dai, J. Li, S. Jia, S. Wang and Y. Liu, Chem. Commun., 2021, 57, 2812 DOI: 10.1039/D1CC00292A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements