Issue 15, 2020

Renal-clearable zwitterionic conjugated hollow ultrasmall Fe3O4 nanoparticles for T1-weighted MR imaging in vivo

Abstract

Monodispersed hollow Fe3O4 nanoparticles with the diameters of 7 and 10 nm were prepared via a high-temperature pyrolysis method and the Kirkendall effect by regulating the ratio of oleylamine to oleic acid. The water solubility was studied by zwitterionic dopamine sulfonate (ZDS) to obtain ZDS-conjugated Fe3O4 nanoparticles (Fe3O4@ZDS NPs). The 7 nm Fe3O4@ZDS NPs exhibited a good T1 positive contrast with a longitudinal relaxivity (r1) of 0.23 mM−1 s−1 and a small ratio of r1 to transversal relaxivity (r2) of 4.00. In the 4T1 xenograft mouse model, the tumor signal from T1-weighted MRI was positively enhanced by ∼23% after the intravenous injection of 7-Fe3O4@ZDS NPs (40 mg kg−1). More importantly, 7-Fe3O4@ZDS NPs can be partially metabolized by the kidney, which is an important step for the use of MRI contrast agents in clinic.

Graphical abstract: Renal-clearable zwitterionic conjugated hollow ultrasmall Fe3O4 nanoparticles for T1-weighted MR imaging in vivo

Supplementary files

Article information

Article type
Paper
Submitted
11 Jan 2020
Accepted
05 Mar 2020
First published
10 Mar 2020

J. Mater. Chem. B, 2020,8, 3087-3091

Renal-clearable zwitterionic conjugated hollow ultrasmall Fe3O4 nanoparticles for T1-weighted MR imaging in vivo

W. Liu, G. Deng, D. Wang, M. Chen, Z. Zhou, H. Yang and S. Yang, J. Mater. Chem. B, 2020, 8, 3087 DOI: 10.1039/D0TB00086H

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