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Molecular recognition with soft biomaterials

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Abstract

Biomacromolecules and engineered materials can achieve molecular recognition if they engage their ligand with properly oriented and chemically complementary moieties. Recently, there has been significant interest in fabricating recognitive soft materials, which possess specific affinity for biological analytes. We present a summary and evaluation of current recognitive materials for biosensing, drug delivery, and regenerative medicine applications. We highlight the impact of material composition on the extent and specificity of ligand adsorption, citing new theoretical and empirical evidence. We conclude with a guide for synthesizing and characterizing novel recognitive materials, as well as recommendations for ligand selection and experimental design.

Graphical abstract: Molecular recognition with soft biomaterials

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Article information


Submitted
03 Oct 2019
Accepted
21 Dec 2019
First published
30 Dec 2019

Soft Matter, 2020, Advance Article
Article type
Perspective

Molecular recognition with soft biomaterials

J. R. Clegg and N. A. Peppas, Soft Matter, 2020, Advance Article , DOI: 10.1039/C9SM01981B

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