Issue 72, 2020

Prescribed drugs containing nitrogen heterocycles: an overview


Heteroatoms as well as heterocyclic scaffolds are frequently present as the common cores in a plethora of active pharmaceuticals natural products. Statistically, more than 85% of all biologically active compounds are heterocycles or comprise a heterocycle and most frequently, nitrogen heterocycles as a backbone in their complex structures. These facts disclose and emphasize the vital role of heterocycles in modern drug design and drug discovery. In this review, we try to present a comprehensive overview of top prescribed drugs containing nitrogen heterocycles, describing their pharmacological properties, medical applications and their selected synthetic pathways. It is worth mentioning that the reported examples are actually limited to current top selling drugs, being or containing N-heterocycles and their synthetic information has been extracted from both scientific journals and the wider patent literature.

Graphical abstract: Prescribed drugs containing nitrogen heterocycles: an overview

Article information

Article type
Review Article
28 Oct 2020
23 Nov 2020
First published
15 Dec 2020
This article is Open Access
Creative Commons BY license

RSC Adv., 2020,10, 44247-44311

Prescribed drugs containing nitrogen heterocycles: an overview

M. M. Heravi and V. Zadsirjan, RSC Adv., 2020, 10, 44247 DOI: 10.1039/D0RA09198G

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