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Iridium-catalyzed arylation of sulfoxonium ylides and arylboronic acids: a straightforward preparation of α-aryl ketones

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Abstract

A highly efficient iridium(III)-catalyzed arylation coupling of sulfoxonium ylides with arylboronic acids to generate α-aryl ketones has been established for the first time. This protocol proceeded under redox-neutral conditions with a wide substrate scope (56 examples, up to 98% yield), high functional group compatibility, easily accessible starting materials and suitability for late-stage modification of structurally complex drug compounds. Further synthetic applications and elaboration of the product were also accomplished.

Graphical abstract: Iridium-catalyzed arylation of sulfoxonium ylides and arylboronic acids: a straightforward preparation of α-aryl ketones

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Article information


Submitted
06 May 2020
Accepted
26 May 2020
First published
27 May 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Iridium-catalyzed arylation of sulfoxonium ylides and arylboronic acids: a straightforward preparation of α-aryl ketones

B. Shu, X. Wang, Z. Shen, T. Che, M. Zhong, J. Song, H. Kang, H. Xie, L. Zhang and S. Zhang, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00543F

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