Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity

Author affiliations

Abstract

A visible light mediated ring expansion of readily available carbo- and heterocyclic anellated cyclopropanes by molecular oxygen at ambient pressure has been developed. Tolerating a variety of functional groups, the reaction yields fused 1,2-dioxolanes, which were tested for antimalarial activity given their close analogy to the active principle of approved drugs such as artemisinin.

Graphical abstract: Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity

Back to tab navigation

Supplementary files

Article information


Submitted
05 Feb 2020
Accepted
06 Apr 2020
First published
09 Apr 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Visible-light mediated oxidative ring expansion of anellated cyclopropanes to fused endoperoxides with antimalarial activity

S. Budde, F. Goerdeler, J. Floß, P. Kreitmeier, E. F. Hicks, O. Moscovitz, P. H. Seeberger, H. M. L. Davies and O. Reiser, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00168F

Social activity

Search articles by author

Spotlight

Advertisements