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Oxidative N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones

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Abstract

A facile route to benzofuran-fused δ-lactones was developed via an N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction, giving the expected products in high yields (up to 99%) with excellent enantioselectivities (up to 98% ee). It should be noted that benzofuran-fused pyrones can be obtained stepwise in one pot with excellent yields (up to 96%) by using this methodology.

Graphical abstract: Oxidative N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones

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Article information


Submitted
04 Feb 2020
Accepted
13 Mar 2020
First published
17 Mar 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Oxidative N-heterocyclic carbene-catalyzed [3 + 3] annulation reaction of enals with benzofuran-3-ones: efficient access to benzofuran-fused δ-lactones

Z. Wang, T. Yang, K. Wang, R. Chen, M. Liu and H. Liu, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/D0QO00161A

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