Issue 13, 2020

Total synthesis study of rauvomines A and B: construction of the pentacyclic core structure

Abstract

A synthetic route has been developed for the core scaffold of rauvomines, which possess an abnormal sarpagine-type backbone without the C20-methylene substitution. The E-ring annulation was achieved by a TiCl4-catalyzed Mukaiyama-Aldol reaction with a moderate yield of 70%.

Graphical abstract: Total synthesis study of rauvomines A and B: construction of the pentacyclic core structure

Supplementary files

Article information

Article type
Research Article
Submitted
26 Dec 2019
Accepted
12 May 2020
First published
18 May 2020

Org. Chem. Front., 2020,7, 1685-1689

Total synthesis study of rauvomines A and B: construction of the pentacyclic core structure

B. Wu, Z. Jiang, J. Tang, Z. Gao, H. Liang, B. Tang, J. Chen and K. Lei, Org. Chem. Front., 2020, 7, 1685 DOI: 10.1039/C9QO01531K

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