Regio- and stereoselective halothiolation of alkynes using lithium halides and N-thiosuccinimides

Abstract

We have developed a highly regioselective halothiolation of alkynes under simple and mild conditions. Our halothiolation reagents are readily available alkali metal halides and N-thiosuccinimides. Our transition metal-free system offers good chemical yields for a wide range of alkyne substrates with satisfactory regioselectivity and good functional group tolerance.