Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 5, 2020
Previous Article Next Article

Stereoselective synthesis of trans-aziridines via intramolecular oxidative C(sp3)–H amination of β-amino ketones

Author affiliations

Abstract

Aziridines are ubiquitous in bioactive molecules and often serve as key synthetic building blocks. We report herein an intramolecular KI/TBHP mediated oxidative dehydrogenative C(sp3)–H amination reaction to synthesize a diverse array of trans-2,3-disubstituted aziridines in good yields under mild conditions. The synthetic utility of this protocol was further highlighted by a one-pot, two-step synthesis of unprotected aziridines.

Graphical abstract: Stereoselective synthesis of trans-aziridines via intramolecular oxidative C(sp3)–H amination of β-amino ketones

Back to tab navigation

Supplementary files

Article information


Submitted
18 Dec 2019
Accepted
24 Jan 2020
First published
04 Feb 2020

Org. Chem. Front., 2020,7, 780-786
Article type
Research Article

Stereoselective synthesis of trans-aziridines via intramolecular oxidative C(sp3)–H amination of β-amino ketones

C. Tan, Y. Liu, X. Liu, H. Jia, K. Xu, S. Huang, J. Wang and J. Tan, Org. Chem. Front., 2020, 7, 780
DOI: 10.1039/C9QO01489F

Social activity

Search articles by author

Spotlight

Advertisements