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Cytotoxic triterpenoids from Antrodia camphorata as sensitizers of paclitaxel

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Abstract

In an attempt to discover anticancer triterpenoids from the medicinal fungus Antrodia camphorata, a total of 60 triterpenoids (1–60) including 18 new ones (antcamphins M–X, 1–18) were isolated from its dish cultures. The structures of the new compounds were elucidated by extensive NMR and HRESIMS data analyses. The absolute configurations were established by the modified Mosher's method, chemical transformation, or X-ray crystallographic data analysis. The cytotoxic activities of 1–60, together with previously reported compounds 61–81, were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7 cells). Compound 57 exhibited potent activities against all the four cell lines with IC50 values of 2.6, 8.2, 2.5, and 4.6 μM, respectively. Moreover, the combination of 10 and 69 (20 μM) could remarkably enhance their cytotoxic activities against the HL60 cells of paclitaxel (10 nM), with inhibition rates increasing from 19.6% to 58.2% and 70.6%, respectively.

Graphical abstract: Cytotoxic triterpenoids from Antrodia camphorata as sensitizers of paclitaxel

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Article information


Submitted
23 Dec 2019
Accepted
27 Jan 2020
First published
11 Feb 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

Cytotoxic triterpenoids from Antrodia camphorata as sensitizers of paclitaxel

B. Li, Y. Kuang, M. Zhang, J. He, L. Xu, C. Leung, D. Ma, J. Lo, X. Qiao and M. Ye, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01516G

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