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A Rh(iii)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides

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Abstract

A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of arylboronic acids, alkynes and CO for the synthesis of butenolides has been developed. The multi-step reaction proceeded smoothly in the presence of [RhCp*Cl2]2 catalyst, NaOAc base and CH3OH additive. The reaction used readily available starting materials, tolerated various functional groups, and afforded valuable butenolides in good yields with high regioselectivity.

Graphical abstract: A Rh(iii)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides

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Article information


Submitted
17 Dec 2019
Accepted
28 Jan 2020
First published
05 Feb 2020

Org. Chem. Front., 2020, Advance Article
Article type
Research Article

A Rh(III)-catalyzed regioselective intermolecular oxa-Pauson–Khand reaction of alkynes, arylboronic acids and CO to form butenolides

M. Zhao, Y. Zhang, N. Ge, L. Yu, S. Wang, Z. Ren and Z. Guan, Org. Chem. Front., 2020, Advance Article , DOI: 10.1039/C9QO01486A

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