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An efficient synthetic approach to novel α-CF3-substituted E-dehydroornithine derivatives and their phosphorus analogues has been developed via the Cu(I)-catalyzed hydroamination of trifluoromethyl-containing α-allenyl-α-aminocarboxylates and α-allenyl-α-aminophosphonates with primary and secondary amines.

Graphical abstract: Synthesis of α-CF3-substituted E-dehydroornithine derivatives via copper(i)-catalyzed hydroamination of allenes

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