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Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis

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Abstract

The current review summarizes the latest achievements in the synthesis of piperidine-2,4-dione-type azaheterocycles. Two main groups traditional (carbonyl compound transformations) and novel (anionic enolate rearrangements) of complementary methods for the simple and effective preparation of structurally diverse compounds in racemic and enantiopure forms have been reported. Due to the specific structure and appropriate reactivity profiles of dione-type molecules, they are a convenient modern platform for the construction of functionalized piperidine-type systems possessing high synthetic and medicinal potential. This potential is successfully realized by the creation of highly active pharmaceutically relevant compounds and the synthesis of natural products.

Graphical abstract: Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis

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Article information


Submitted
09 Feb 2020
Accepted
16 Mar 2020
First published
16 Mar 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Research Article

Construction of piperidine-2,4-dione-type azaheterocycles and their application in modern drug development and natural product synthesis

R. M. Tikhov and N. Yu. Kuznetsov, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/D0OB00287A

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