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Issue 13, 2020
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Construction of key building blocks towards the synthesis of cortistatins

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Abstract

This work reports the construction of key building blocks towards the synthesis of cortistatins; a family of steroidal alkaloids. Cortistatin A, being a primary target due to its superior biological properties over other congeners, has been prepared by two different synthetic routes. Synthesis of the precursor to the heavily substituted A-ring starting from D-glucose and construction of the DE-ring junction employing a Hajos–Parrish ketone as a chiral pool have been demonstrated. Efforts are underway to assemble these key fragments and build towards the total synthesis of cortistatin A.

Graphical abstract: Construction of key building blocks towards the synthesis of cortistatins

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Article information


Submitted
25 Jan 2020
Accepted
02 Mar 2020
First published
02 Mar 2020

Org. Biomol. Chem., 2020,18, 2432-2446
Article type
Paper

Construction of key building blocks towards the synthesis of cortistatins

S. Indu, R. D. Telore and K. P. Kaliappan, Org. Biomol. Chem., 2020, 18, 2432
DOI: 10.1039/D0OB00170H

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