Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Experimental and theoretical study on the cyclic(alkyl)(amino)carbene-copper catalyzed Friedel–Crafts reaction of N,N-dialkylanilines with styrenes

Author affiliations

Abstract

The Friedel–Crafts reaction of alkalinous substrates is challenging because of the coordination between amines and traditional acid catalysts. Based on theoretical research, we designed a catalytic process for the Friedel–Crafts reactions of N,N-dialkylanilines in the presence of CAAC-CuCl [CAAC = cyclic(alkyl)(amino)carbene] and KB(C6F5)4. Experimental results show that the catalytic system is suitable for a series of N,N-dialkylanilines and styrenes with good to excellent yields of para-selectivity products. The results are comparable to those obtained in carbene-gold catalyzed processes.

Graphical abstract: Experimental and theoretical study on the cyclic(alkyl)(amino)carbene-copper catalyzed Friedel–Crafts reaction of N,N-dialkylanilines with styrenes

Back to tab navigation

Supplementary files

Article information


Submitted
24 Dec 2019
Accepted
18 May 2020
First published
18 May 2020

Org. Biomol. Chem., 2020, Advance Article
Article type
Paper

Experimental and theoretical study on the cyclic(alkyl)(amino)carbene-copper catalyzed Friedel–Crafts reaction of N,N-dialkylanilines with styrenes

W. Ma, G. Zhai, X. Hu and Y. Wu, Org. Biomol. Chem., 2020, Advance Article , DOI: 10.1039/C9OB02734C

Social activity

Search articles by author

Spotlight

Advertisements