Issue 22, 2020

Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer

Abstract

The hydrogen-bonding-assisted construction of tetrahydroquinolines decorated with structurally diverse 3,3′-difunctional groups has been realized via a hydride transfer-involved three-step cascade reaction in the presence of morpholine. This protocol solves the limitation of acyclic 1,3-dicarbonyl compounds by one-pot synthesis of tetrahydroquinolines, featuring operational simplicity, broadly applicable substrates, and metal- and acid-free conditions with EtOH as a hydrogen-bonding donor.

Graphical abstract: Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer

Supplementary files

Article information

Article type
Paper
Submitted
11 Mar 2020
Accepted
18 May 2020
First published
22 May 2020

Org. Biomol. Chem., 2020,18, 4267-4271

Hydrogen-bonding-assisted redox-neutral construction of tetrahydroquinolines via hydride transfer

X. Yang, F. Hu, L. Wang, L. Xu and S. Li, Org. Biomol. Chem., 2020, 18, 4267 DOI: 10.1039/D0OB00521E

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