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Issue 8, 2020
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Sequential conjugation methods based on triazole formation and related reactions using azides

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Abstract

The recent remarkable progress in azide chemistry has realized sequential conjugation methods with selective 1,2,3-triazole formation. On the basis of the diverse reactivities of azides and azidophiles, including terminal alkynes and cyclooctynes, various selective reactions to furnish triazoles and a wide range of platform molecules, such as diynes, diazides, triynes, and triazides, have been developed so far for bis- and tris(triazole) syntheses. This review highlights recent transformations involving selective triazole formation, allowing the efficient preparation of unsymmetric bis- and tris(triazole)s using diverse platform molecules.

Graphical abstract: Sequential conjugation methods based on triazole formation and related reactions using azides

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Article information


Submitted
19 Dec 2019
Accepted
23 Jan 2020
First published
23 Jan 2020

Org. Biomol. Chem., 2020,18, 1550-1562
Article type
Review Article

Sequential conjugation methods based on triazole formation and related reactions using azides

S. Yoshida, Org. Biomol. Chem., 2020, 18, 1550
DOI: 10.1039/C9OB02698C

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