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Issue 3, 2020
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The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

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Abstract

The growing threat of antibacterial resistance is a global concern. The so-called calcium-dependent lipopeptide antibiotics (CDAs) have emerged as a promising source of new antibiotic agents that are rich in structural and mechanistic diversity. Over forty unique CDAs have been identified to date and share a number of common features. Recent efforts in our group have provided new mechanistic and structural insights into the laspartomycin family of CDAs. We here describe investigations aimed at probing the role of the three glycine residues found in the laspartomycin peptide macrocycle. In doing so laspartomycin analogues containing the achiral 2-aminoisobutyric acid (AIB) as well as L- or D-alanine in place of glycine were prepared and their antibacterial activities evaluated.

Graphical abstract: The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

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Supplementary files

Article information


Submitted
26 Nov 2019
Accepted
11 Dec 2019
First published
12 Dec 2019

This article is Open Access

Org. Biomol. Chem., 2020,18, 514-517
Article type
Paper

The contribution of achiral residues in the laspartomycin family of calcium-dependent lipopeptide antibiotics

T. M. Wood, K. Bertheussen and N. I. Martin, Org. Biomol. Chem., 2020, 18, 514
DOI: 10.1039/C9OB02534K

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