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Advanced Nanomaterials for Hypoxia Tumor Therapy: Challenges and Solution


In recent trends, nanomaterials and nanotechnology have emerged as vital factors in the medical field with a unique contribution to cancer medicine. Given the increasing number of cancer patients, it is necessarily required to develop innovative strategies and therapeutic modalities to tackle hypoxia, which forms a hallmark and great barrier in treating solid tumours. The present review details about the challenges in nanotechnology-based hypoxia targeting strategies and solutions for better therapeutic performances. The interaction between hypoxia and tumor is firstly introduced. Then we review the recently developed engineered nanomaterials towards multimodal hypoxia tumor therapies, including chemotherapy, radiotherapy, sonodynamic treatment. In the next part, we summarize the nanotechnology-based strategies for overcoming hypoxia problems. Finally, current challenges and future directions are proposed for the successful prevail of the hypoxia tumor problems

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Article information

31 Aug 2020
07 Oct 2020
First published
15 Oct 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Review Article

Advanced Nanomaterials for Hypoxia Tumor Therapy: Challenges and Solution

A. Sundaram, L. Peng, L. Chai, Z. Xie, J. S. Ponraj, X. Wang, G. Wang, B. Zhang, G. Nie, N. Xie, M. Rajesh Kumar and H. Zhang, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/D0NR06271E

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