Issue 42, 2020

Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

Abstract

Hypoxia, as a typical factor in a tumor microenvironment, plays a vital role in tumor treatment resistance, tumor invasion and migration. Hypoxia inducible factor (HIF), as the vital response element of hypoxia, mediates these untoward effects through a series of downstream reactions. Cancer treatments such as photodynamic therapy (PDT), radiotherapy (RT) and chemotherapy are severely hindered by hypoxia and HIF, back, however, could be intelligently manipulated through nanocomposite materials for their great potentiality to combine different functions. Herein, we reviewed the smart strategies in emerging research studies to overcome hypoxia toward the enhancement of tumor therapy.

Graphical abstract: Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

Article information

Article type
Review Article
Submitted
24 Jul 2020
Accepted
26 Sep 2020
First published
28 Sep 2020

Nanoscale, 2020,12, 21519-21533

Smart strategies to overcome tumor hypoxia toward the enhancement of cancer therapy

M. Xu, P. Wang, S. Sun, L. Gao, L. Sun, L. Zhang, J. Zhang, S. Wang and X. Liang, Nanoscale, 2020, 12, 21519 DOI: 10.1039/D0NR05501H

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