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Functional Nanoarrays for Investigating Stem Cell Fate and Function

Abstract

Stem cells offers excellent potential in the field of tissue engineering and regenerative medicine based on their excellent capability to not only self-renew but also differentiate into a specialized cell type of interest. However, the lack of a non-destructive monitoring system renders it challenging to identify and characterize differentiated cells before their transplantation without compromising cell viability. Thus, the development of a non-destructive monitoring method for analyzing cell function is highly desired and can significantly benefit stem cell-based therapies. Recently, nanomaterial-based scaffolds (e.g., nanoarray) have made possible considerable advances in controlling the differentiation of stem cells and characterization ofing the differentiation status sensitively in realtime. This review provides a selective overview of the recent progress in synthesis methods of nanoarray as well as its applications for controlling stem cell fate and monitoring live cell functions electrochemically. We believe the topics discussed in this review can provide a brief and concise guideline in the development of novel nanoarrays and promote the interest in live cell study applications. The A method which that can not only control but also monitor stem cell fate and function will be a promising technology that can accelerate stem cell therapies.

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Article information


Submitted
30 Dec 2019
Accepted
07 Feb 2020
First published
13 Feb 2020

Nanoscale, 2020, Accepted Manuscript
Article type
Review Article

Functional Nanoarrays for Investigating Stem Cell Fate and Function

J. Lee, J. Luo, H. K. Choi, S. D. Chueng, K. Lee and J. Choi, Nanoscale, 2020, Accepted Manuscript , DOI: 10.1039/C9NR10963C

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