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Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities

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Abstract

Covering: 2010 to 2020

The class of 2,11-cyclized cembranoids is particularly widespread in marine Octocorallia, especially Alcyonacea and Gorgonacea, and has been extensively studied. Following a previous review published in 2010, the accumulated knowledge from the past decade will be presented here. All 2,11-cyclized cembranoids share a bicyclo[8.4.0]tetradecane core that is in most of the known compounds oxidatively modified to result in the 15-oxatricyclo[6.6.1.02,7]pentadecane system. Multiple further oxidation and acylation patterns can be observed, while halogenated compounds are surprisingly rare. One new sulfur-containing and a few seco-compounds have also been reported. The biosynthetic pathways to this fascinating class of natural products have not been studied to date, but a plausible biosynthetic hypothesis is presented that allows for a structured discussion of the compounds according to their carbon skeletons and oxidation patterns. Biological activities towards 2,11-cyclized diterpenes are also included.

Graphical abstract: Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities

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Article information


Submitted
31 Mar 2020
First published
27 May 2020

Nat. Prod. Rep., 2020, Advance Article
Article type
Review Article

Diving into the world of marine 2,11-cyclized cembranoids: a summary of new compounds and their biological activities

G. Li, J. S. Dickschat and Y. Guo, Nat. Prod. Rep., 2020, Advance Article , DOI: 10.1039/D0NP00016G

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