One-Step Facile Synthesis of Au@Copper-Tannic Acid Coordination Core-Shell Nanostructures Served as Photothermal-Enhanced ROS Generator for Synergistic Tumour Therapy
Integrating reactive oxygen species (ROS)-based catalytic therapy and photothermal therapy into one single nanosystem is an inspiring therapeutic approach for tumour. Herein, a multifunctional Au nanoparticle with copper-tannic acid coordination core-shell nanostructures (Au@TACu NSs) was fabricated through one-step method. The obtained Au@TACu NSs possessed superior hyperthermia effect for tumour ablation, as well as preferential peroxidase-like activity to induce toxic hydroxyl radicals (·OH) production by the decomposition of H2O2 for oxidation therapy. Notably, the hyperthermia effect and GSH-depleting capability of Au@TACu NSs can further amplify ·OH production, achieving a photothermal-enhanced oxidation therapy (PTT/OT). Moreover, such synergistic therapy strategy showed highly efficient inhibition of tumour growth in vivo with unnoticeable tissue damage. Our work provides insights for Au-based nanomaterials as theranostic agents for PTT/OT synergistic tumour therapy.