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One-Step Facile Synthesis of Au@Copper-Tannic Acid Coordination Core-Shell Nanostructures Served as Photothermal-Enhanced ROS Generator for Synergistic Tumour Therapy

Abstract

Integrating reactive oxygen species (ROS)-based catalytic therapy and photothermal therapy into one single nanosystem is an inspiring therapeutic approach for tumour. Herein, a multifunctional Au nanoparticle with copper-tannic acid coordination core-shell nanostructures (Au@TACu NSs) was fabricated through one-step method. The obtained Au@TACu NSs possessed superior hyperthermia effect for tumour ablation, as well as preferential peroxidase-like activity to induce toxic hydroxyl radicals (·OH) production by the decomposition of H2O2 for oxidation therapy. Notably, the hyperthermia effect and GSH-depleting capability of Au@TACu NSs can further amplify ·OH production, achieving a photothermal-enhanced oxidation therapy (PTT/OT). Moreover, such synergistic therapy strategy showed highly efficient inhibition of tumour growth in vivo with unnoticeable tissue damage. Our work provides insights for Au-based nanomaterials as theranostic agents for PTT/OT synergistic tumour therapy.

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Supplementary files

Article information


Submitted
05 Sep 2020
Accepted
13 Oct 2020
First published
16 Oct 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

One-Step Facile Synthesis of Au@Copper-Tannic Acid Coordination Core-Shell Nanostructures Served as Photothermal-Enhanced ROS Generator for Synergistic Tumour Therapy

Y. Liu, Q. Shi, Y. Zhang, J. Jing and J. Pei, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0NJ04460A

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