Jump to main content
Jump to site search


Nanoconjugates of graphene oxide derivatives and meso-tetraphenylporphyrin: A new avenue for anticancer photodynamic therapies - Cell-on-a-Chip analysis

Abstract

In this study the possibility of using four different GO derivatives as a nanocarriers for meso-tetrafenylporphyrin (TPP) (GO_TPP) was evaluated. The research was carried with the innovative, well-reproducing tumor environment 2D and 3D MCF-7/HMF co-cultures performed in a single microfluidic Cell-on-a-Chip system. A significant accumulation of TPP in cancer cells for the tested GO_TPP nanoconjugates was achieved. It resulted in a decrease of MCF-7/HMF cell viability cultured as a 2D and 3D models. Our research confirmed that the driving force of a decrease of MCF-7/HMF cell viability after PDT procedures with GO_TPP was associated with the efficient generation of reactive oxygen species (ROS). It was proved that the tested conjugates did not show any cytotoxic effect of MCF-7/HMF co-cultures without irradiation. Therefore, the herein presented nanoconjugates can be treated as the non-toxic materials for humans that after activation can be applied as the highly efficient probes for the PDT.

Back to tab navigation

Supplementary files

Article information


Submitted
19 Aug 2020
Accepted
28 Sep 2020
First published
09 Oct 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

Nanoconjugates of graphene oxide derivatives and meso-tetraphenylporphyrin: A new avenue for anticancer photodynamic therapies - Cell-on-a-Chip analysis

A. Zuchowska, A. Kasprzak, B. Dabrowski, K. Kaminska, M. Popławska and Z. Brzozka, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/D0NJ04189K

Social activity

Search articles by author

Spotlight

Advertisements