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Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib

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Abstract

The voltammetric responses of two anticancer molecules irinotecan (ITC) and sunitinib (SUN) were investigated at glassy carbon (GC) and indium tin oxide (ITO) electrodes bare or modified with carbon nanotubes (NTs), NT–Nafion composites (NafionNTs) and poly(3,4-ethylenedioxy-thiophene) (PEDOT). Bare GC electrodes revealed to be the most suitable for the detection of drugs at low concentration levels. Differential pulse voltammetry (DPV) analyses showed that the responses of the anticancer molecules are affected by the formation of aggregates. In particular, aggregation of SUN results in the formation of H-aggregates. DPV analysis extended to human plasma samples revealed the drugs in micromolar concentrations with good reproducibility.

Graphical abstract: Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib

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Supplementary files

Article information


Submitted
03 Aug 2020
Accepted
10 Sep 2020
First published
29 Sep 2020

This article is Open Access

New J. Chem., 2020, Advance Article
Article type
Paper

Voltammetric responses at modified electrodes and aggregation effects of two anticancer molecules: irinotecan and sunitinib

B. Vercelli, S. Crotti and M. Agostini, New J. Chem., 2020, Advance Article , DOI: 10.1039/D0NJ03896B

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