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Tuned structure and DNA binding properties of metal complexes base on a new 4-acylpyrazolone derivative

Abstract

It is a common knowledge that the spatial structure of substrates is the major influencing factor for DNA binding. To tune the binding affinity of DNA, three complexes based on a new 4-acylpyrazolone derivative ligand, (2-hydroxy-N'-((5-hydroxy-3-methyl-1-(4-nitrophenyl)-4,5-dihydro-1H-pyrazol-4-yl)(phenyl)methylene)benzohydrazide) (H2L), has been prepared and well characteristized. Reaction of H2L with CuCl2 resulted a mononuclear compound with tetra-coordinated quadrilateral plane, [Cu(HL)Cl] (1). When H2L was coordinated to Cu(OAc)2, a dinuclear Cu(II) compound with chemical formula of [Cu2L2(CH3OH)2]∙CH3OH (2) was obtained and the coordination geometry of Cu(II) is a square pyramid. Upon assembled H2L with Mn(OAc)2, a quite different dinuclear compound with chemical compisition of [Mn2L2(CH3OH)2(H2O)2]∙CH3OH (3) were afforded where Mn(III) displayed distorted octahedron configurations. DNA binding studies were performed on H2L and its three complexes by electron absorption titration and EB-DNA competition experiments, and the results indicat they all bind DNA in an intercalation mode and their binding affinity follows 1 > 2 > 3 > H2L. In addition, the Time Dependent Density Functional Theory (TD-DFT) calculation were performed for H2L and its three complexes to better clarifies the electronic transitions in the UV-Vis spectra.

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Supplementary files

Article information


Submitted
30 Nov 2019
Accepted
06 Jan 2020
First published
07 Jan 2020

New J. Chem., 2020, Accepted Manuscript
Article type
Paper

Tuned structure and DNA binding properties of metal complexes base on a new 4-acylpyrazolone derivative

W. Xi, F. Song, X. Song and X. Song, New J. Chem., 2020, Accepted Manuscript , DOI: 10.1039/C9NJ05948B

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